Multitasking in Gonadotropin-Releasing Hormone Neuron Dendrites
ثبت نشده
چکیده
Gonadotropin-releasing hormone (GnRH) neurons integrate synaptic information in their dendrites in order to precisely control GnRH secretion and hence fertility. Recent discoveries concerning the structure and function of GnRH neuron dendrites have shed new light on the control of GnRH neuron excitability and GnRH secretion. This work suggests that GnRH neurons have a unique projection to the median eminence that possesses both dendritic and axonal properties. We propose that this ‘dendron’ projection allows GnRH neurons to multitask and integrate information in ways that would not be possible in a classically envisioned axon projection. © 2014 S. Karger AG, Basel
منابع مشابه
Multitasking in Gonadotropin-Releasing Hormone Neuron Dendrites
Gonadotropin-releasing hormone (GnRH) neurons integrate synaptic information in their dendrites in order to precisely control GnRH secretion and hence fertility. Recent discoveries concerning the structure and function of GnRH neuron dendrites have shed new light on the control of GnRH neuron excitability and GnRH secretion. This work suggests that GnRH neurons have a unique projection to the m...
متن کاملMultitasking in Gonadotropin-Releasing Hormone Neuron Dendrites.
Gonadotropin-releasing hormone (GnRH) neurons integrate synaptic information in their dendrites in order to precisely control GnRH secretion and hence fertility. Recent discoveries concerning the structure and function of GnRH neuron dendrites have shed new light on the control of GnRH neuron excitability and GnRH secretion. This work suggests that GnRH neurons have a unique projection to the m...
متن کاملInitiation and propagation of action potentials in gonadotropin-releasing hormone neuron dendrites.
Gonadotropin-releasing hormone (GnRH) neurons are the final output neurons in a complex neuronal network that regulates fertility. The morphology of GnRH neuron dendrites is very different to other central neurons in that they are very long, thin, and unbranched. To study the function of these dendrites, we have used Na(+) and Ca(2+) imaging in combination with dual soma and dendrite electrical...
متن کاملEph Receptors Tingle the Spine
During the development of excitatory synapses, molecules cluster on dendrites to form postsynaptic densities, and specialized structures known as spines appear. EphB2 is demonstrated to control this process by associating with and phosphorylating a key postsynaptic molecule, syndecan-2, thereby initiating the maturation of dendritic spines.
متن کاملTREATMENT OF PRECOCIOUS PUBERTY BY A LONG-ACTING GONADOTROPIN-RELEASING HORMONE ANALOGUE IN CHILDREN
The GnRH analogue has been shown to be effective in the treatment of precocious puberty when given as a daily subcutaneous injection. We studied the effectiveness of a long-acting GnRH analogue, Triptoreline, for the treatment of central precocity, by suppressing gonadotropin and estradiol secretion in three children with true precocious puberty. One month after single dose intramuscular i...
متن کامل